【Abstract】 Objective To explore the epidemiological characteristics of hemorrhagic fever with renal syndrome(HFRS) in Zhejiang province for establishing pertinent prevention strategy. Methods Descriptive epidemiology method was applied for the analysis of epidemic situation. The antibody in the serum of HFRS patients was detected by indirect immunoflorscence method, and the HV antigen in the rodent lung was assayed by direct immunoflorscence method. Results There were 757 cases in the whole province in 2007, mainly distributed in Ningbo, Shaoxing, Taizhou, Lishui and Quzhou, accounting for about 86.79% of the total （657/757）. There were two incidence peaks in summer, winter and spring. Most of the cases were young and middle?aged peasants. Conclusion The incidence rate of HFRS in Zhejiang province has been stable in recent years, but it was still high in some counties and cities. Therefore, the prevention and control of HFRS in the main epidemic areas should be strengthened.